Manchester United bolstered their squad with a flurry of transfer deadline day signings, Manchester City and Liverpool also splashed out while ambitious Brighton & Hove Albion sealed an audacious loan deal for Barcelona's Ansu Fati on Friday.
The victory moved United up to fifth with nine points from five matches, six adrift of leaders Arsenal and four behind second-placed Manchester City. Leicester stay bottom on one point.
Liverpool hammered seven past Manchester United to keep their top-four bid alive in the Premier League.
Manchester United's Paul Pogba is desperate to make up for lost time after his long injury absence, manager Ole Gunnar Solskjaer said after the France midfielder impressed in Friday's 1-1 draw with Tottenham Hotspur.
English Premier League champions Manchester City cruised to a 2-0 win over struggling Manchester United in their derby at Old Trafford on Saturday.
Manchester United conceded two late own goals to allow Sevilla to snatch a 2-2 draw in the first leg of their Europa League quarter-final at Old Trafford on Thursday.
Nadal appeared close to retiring mid-match but found the will to beat Fritz
Players from newly-crowned Premier League champions Manchester City dominated the Professional Footballers' Association's (PFA) Team of the Year announced on Wednesday, occupying five out of 11 spots.
IMAGES from the English Premier League matches played on Tuesday.
Leicester keeper Schmeichel defends under-fire De Gea
Second-half goals from substitutes Fred and Anthony Elanga earned Manchester United a 4-2 victory over Leeds United in a thriller at Elland Road in the Premier League on Sunday.
'With all the foot issues, just turned 36, he adds his 22nd Major'
Images from Sunday's action in the Premier League
Scott McTominay's header proved decisive for Manchester United
Manchester United suffered their first defeat under interim manager Ralf Rangnick, falling to a 1-0 loss at home to Wolverhampton Wanderers in the English Premier League on Monday.
The teams finished level at 3-3 on aggregate in the tie but the Lisbon club advanced to the quarter-finals after Adan kept out Martinelli's weak effort.
Liverpool's first loss of the season means they cannot finish the campaign unbeaten to match Arsenal's 'Invincibles' of 2003-04.
Mourinho was also adamant that it was crucial to United's ambitions to keep the 28-year-old Spain international, who has been linked with French champions Paris St Germain.
A weakened Manchester United were beaten 2-1 at home by Leicester City on Tuesday, ending Manchester City's wait to be crowned Premier League champions.
News of all that transpired on and off the football field
A summary of Saturday's action in the Premier League.
'Hopefully, for many years,Marcus Rashford will be in this club and can make history for the club.'
After a tense encounter finished 1-1 following extra time, Villareal's Rulli stepped up after every on-field player scored their spot kicks and he comfortably beat Spaniard De Gea
IMAGES from the English Premier League matches played on Sunday.
Roundup of Champions League matches played on Wednesday night
A summary of Sunday's action in the Premier League.
Manchester United crushed Newcastle United's hopes of a claiming a first domestic trophy for nearly 70 years with a clinical 2-0 victory in the League Cup final at Wembley on Sunday.
Spain are still favourites to finish top of Group E above Sweden, Poland and Slovakia but, after struggling to break down conservative sides such as Georgia and Greece in March, they know coming first will not be a procession.
It was a night of mixed emotions at the Camp Nou on Saturday as FC Barcelona's veteran midfielder and captain, Xavi, known for his slick short passes, played his final La Liga match against Deportivo la Coruna.
United, who had Nemanja Matic sent off for a second bookable offence in injury time, had an early effort from Alexis Sanchez disallowed for offside but soon took command via a scrappy 35th-minute effort from Romelu Lukaku and a superb left-foot volley from Chris Smalling three minutes later.
'I can't give you a time but we will get there. We have given ourselves a big, big uphill task to get in the top four, never mind the top six'
IMAGES from the Champions League matches played on Tuesday.
Photos from the English Premier League match played between Manchester United and Arsenal on Saturday
An ecstatic home crowd at a noisy and rainy John Smith's Stadium celebrated what was the Yorkshire club's first win over United since 1952 and one which few would doubt they deserved after a passionate display.
Manchester United are facing an injury crisis
Rediff.com gives you a glimpse of the celebrations.
Pogba said last month that he could seek a new challenge after three years at United, while his agent recently told The Times that the 26-year-old intends to leave the club amid reports linking him to Juventus and Real Madrid.
Goalkeeper David de Gea believes the busy holiday fixture list offers the perfect opportunity for Manchester United to put some pressure on the Premier League's top two clubs.
United looked more solid after the introduction of midfielder Nemanja Matic at the break and got a foothold in the tie through a 70th-minute goal from Marcus Rashford.
Images from the English Premier League matches played on Saturday
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